Angiosarcoma is most common in older adults and often involves which organs?

• A. Lungs, brain, kidneys
• B. Skin, breast, soft tissue, liver
• C. Lymph nodes, spleen, intestine
• D. Pancreas, stomach, colon

Answer: (B)

Angiosarcoma is a malignant tumor derived from endothelial cells, and in older adults its most common sites reflect where it tends to arise primordially. The skin is the classic and most frequent location, often on the scalp or face, with the breast being a notable site, especially in the setting of chronic lymphedema after mastectomy (Stewart‑Treves syndrome). It can also arise in soft tissues and, less commonly, in the liver where toxin exposure (like vinyl chloride, arsenic, or Thorotrast) increases risk. This combination—skin, breast, soft tissue, and liver—best captures the typical organ involvement pattern for angiosarcoma in older adults. Other organs listed can be involved, but they are not the hallmark primary sites for this tumor.