Classic PAN is what kind of necrosis leading to ischemia/infarction?

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Study for the CVP and GI Pathology Exam 1. Engage with flashcards and multiple-choice questions, each with hints and explanations. Prepare thoroughly for your test!

Multiple Choice

Classic PAN is what kind of necrosis leading to ischemia/infarction?

Explanation:
Classic PAN features necrotizing inflammation of medium-sized arteries with fibrinoid necrosis. In this process, immune complexes and fibrin leak into the vessel wall, producing a bright pink, fibrin-like deposition. This weakens and devastates the vessel wall, commonly narrowing or occluding the lumen and causing ischemia and infarction in organs supplied by those arteries. Other necrosis types—fat necrosis, caseous necrosis, or liquefactive necrosis—occur in different settings and are not characteristic of PAN, whereas the fibrinoid pattern is the hallmark here.

Classic PAN features necrotizing inflammation of medium-sized arteries with fibrinoid necrosis. In this process, immune complexes and fibrin leak into the vessel wall, producing a bright pink, fibrin-like deposition. This weakens and devastates the vessel wall, commonly narrowing or occluding the lumen and causing ischemia and infarction in organs supplied by those arteries. Other necrosis types—fat necrosis, caseous necrosis, or liquefactive necrosis—occur in different settings and are not characteristic of PAN, whereas the fibrinoid pattern is the hallmark here.

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