In beta-thalassemia, which globin will form unstable aggregates that result in RBC destruction?

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Study for the CVP and GI Pathology Exam 1. Engage with flashcards and multiple-choice questions, each with hints and explanations. Prepare thoroughly for your test!

Multiple Choice

In beta-thalassemia, which globin will form unstable aggregates that result in RBC destruction?

Explanation:
In beta-thalassemia the problem is a shortage of beta-globin, which leaves alpha-globin chains in excess. These unpaired alpha chains are unstable and precipitate within developing erythroid cells and in circulating red cells, forming insoluble aggregates that damage the cell membrane and cytoskeleton. This leads to red cell destruction, both through ineffective erythropoiesis in the marrow and hemolysis in the spleen. So the globin forming the unstable aggregates in this scenario is the alpha-globin chain.

In beta-thalassemia the problem is a shortage of beta-globin, which leaves alpha-globin chains in excess. These unpaired alpha chains are unstable and precipitate within developing erythroid cells and in circulating red cells, forming insoluble aggregates that damage the cell membrane and cytoskeleton. This leads to red cell destruction, both through ineffective erythropoiesis in the marrow and hemolysis in the spleen. So the globin forming the unstable aggregates in this scenario is the alpha-globin chain.

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