In von Willebrand disease, laboratory evaluation has abnormal platelet ______ and coagulation.

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Study for the CVP and GI Pathology Exam 1. Engage with flashcards and multiple-choice questions, each with hints and explanations. Prepare thoroughly for your test!

Multiple Choice

In von Willebrand disease, laboratory evaluation has abnormal platelet ______ and coagulation.

Explanation:
Von Willebrand factor is crucial for platelets to adhere to damaged vessels and it also stabilizes factor VIII. When vWD is present, platelets can’t function properly in initiating a hemostatic plug because their adhesion to exposed collagen is impaired, which shows up as abnormal platelet function. At the same time, reduced vWF means less stabilized factor VIII, so the coagulation cascade is affected, giving an abnormal coagulation profile. That combination—defective platelet function with coagulation abnormalities—captures the common laboratory pattern in von Willebrand disease, making this description the best fit.

Von Willebrand factor is crucial for platelets to adhere to damaged vessels and it also stabilizes factor VIII. When vWD is present, platelets can’t function properly in initiating a hemostatic plug because their adhesion to exposed collagen is impaired, which shows up as abnormal platelet function. At the same time, reduced vWF means less stabilized factor VIII, so the coagulation cascade is affected, giving an abnormal coagulation profile. That combination—defective platelet function with coagulation abnormalities—captures the common laboratory pattern in von Willebrand disease, making this description the best fit.

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