Which antibody is present in less than 50% of Churg-Strauss syndrome cases?

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Study for the CVP and GI Pathology Exam 1. Engage with flashcards and multiple-choice questions, each with hints and explanations. Prepare thoroughly for your test!

Multiple Choice

Which antibody is present in less than 50% of Churg-Strauss syndrome cases?

Explanation:
In eosinophilic granulomatosis with polyangiitis (Churg-Strauss), the most commonly detected antibody is MPO-ANCA in a perinuclear pattern (p-ANCA), but it’s not present in all patients. This pattern appears in roughly a third to about 40% of cases, i.e., less than half. The PR3-ANCA (C-ANCA) pattern is less typical for this disease, while ANA and RF are nonspecific and not characteristic findings. Therefore, the antibody present in less than 50% of cases is P-ANCA.

In eosinophilic granulomatosis with polyangiitis (Churg-Strauss), the most commonly detected antibody is MPO-ANCA in a perinuclear pattern (p-ANCA), but it’s not present in all patients. This pattern appears in roughly a third to about 40% of cases, i.e., less than half. The PR3-ANCA (C-ANCA) pattern is less typical for this disease, while ANA and RF are nonspecific and not characteristic findings. Therefore, the antibody present in less than 50% of cases is P-ANCA.

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