Which condition is an example of an acquired coagulation factor deficiency?

• A. Liver disease
• B. Hemophilia A
• C. Von Willebrand disease
• D. Hemophilia B

Answer: (A)

Acquired coagulation factor deficiencies arise when the body's ability to produce factors is impaired by another process, such as liver disease. The liver is the central organ for synthesizing most coagulation factors (including factors II, V, VII, IX, X, and others). When liver function is compromised, production of these factors declines, leading to a bleeding tendency and prolonged clotting times. This contrasts with inherited conditions like hemophilia A (factor VIII deficiency) and hemophilia B (factor IX deficiency), and von Willebrand disease, which are genetic in origin rather than due to an organ failure. So liver disease fits as the acquired deficiency because the defect stems from reduced hepatic synthesis of coagulation factors.