Which of the following is NOT an acquired clotting factor deficiency?

• A. Hemophilia A
• B. Liver Disease
• C. DIC
• D. Vitamin K deficiency

Answer: (A)

The key idea is that some clotting factor deficiencies are inherited, while others are acquired from an illness or nutritional issue. Hemophilia A is an inherited deficiency of factor VIII due to a mutation in the F8 gene and is typically passed down in families (X‑linked recessive). Because it’s congenital, it’s not caused by factors like liver injury, vitamin K deficiency, or a consumption coagulopathy, which are the classic examples of acquired deficiencies. In contrast, vitamin K deficiency lowers the vitamin K–dependent factors (II, VII, IX, X); liver disease reduces synthesis of several clotting factors; and DIC consumes clotting factors, all representing acquired problems. Since Hemophilia A is caused by a genetic defect present from birth rather than a result of an acquired condition, it is the NOT acquired deficiency.