Which signaling pathway is implicated in hereditary hemorrhagic telangiectasia?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Study for the CVP and GI Pathology Exam 1. Engage with flashcards and multiple-choice questions, each with hints and explanations. Prepare thoroughly for your test!

Multiple Choice

Which signaling pathway is implicated in hereditary hemorrhagic telangiectasia?

Explanation:
Hereditary hemorrhagic telangiectasia is driven by mutations in ENG and ACVRL1, which encode components of the TGF-beta/BMP signaling axis in endothelial cells. This signaling pathway governs endothelial cell behavior and vessel maturation; when it’s disrupted, normal angiogenesis is perturbed, leading to fragile telangiectasias and arteriovenous malformations that bleed. Downstream SMAD signaling is affected, promoting abnormal vessel formation. While Notch, Wnt, and Hedgehog pathways also influence blood vessels, they are not the primary pathway implicated in this condition.

Hereditary hemorrhagic telangiectasia is driven by mutations in ENG and ACVRL1, which encode components of the TGF-beta/BMP signaling axis in endothelial cells. This signaling pathway governs endothelial cell behavior and vessel maturation; when it’s disrupted, normal angiogenesis is perturbed, leading to fragile telangiectasias and arteriovenous malformations that bleed. Downstream SMAD signaling is affected, promoting abnormal vessel formation. While Notch, Wnt, and Hedgehog pathways also influence blood vessels, they are not the primary pathway implicated in this condition.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy