Which statement about von Willebrand disease is true?

Study for the CVP and GI Pathology Exam 1. Engage with flashcards and multiple-choice questions, each with hints and explanations. Prepare thoroughly for your test!

Multiple Choice

Which statement about von Willebrand disease is true?

Explanation:
Von Willebrand disease is most commonly inherited in an autosomal dominant pattern. A single mutated copy of the VWF gene can lead to reduced or defective von Willebrand factor, so carriers in successive generations may show symptoms in both sexes. This explains why the dominant inheritance statement fits the typical forms (especially type 1 and many type 2 variants) and why it’s the best general description. There are rare autosomal recessive cases (notably type 3) with more severe bleeding, but they are much less common. The condition is not X-linked or mitochondrial, which would show different family patterns.

Von Willebrand disease is most commonly inherited in an autosomal dominant pattern. A single mutated copy of the VWF gene can lead to reduced or defective von Willebrand factor, so carriers in successive generations may show symptoms in both sexes. This explains why the dominant inheritance statement fits the typical forms (especially type 1 and many type 2 variants) and why it’s the best general description. There are rare autosomal recessive cases (notably type 3) with more severe bleeding, but they are much less common. The condition is not X-linked or mitochondrial, which would show different family patterns.

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