Which type of von Willebrand disease is autosomal recessive and most severe?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Study for the CVP and GI Pathology Exam 1. Engage with flashcards and multiple-choice questions, each with hints and explanations. Prepare thoroughly for your test!

Multiple Choice

Which type of von Willebrand disease is autosomal recessive and most severe?

Explanation:
Understanding how inheritance and VWF levels affect bleeding helps explain why this is the most severe form. Von Willebrand factor promotes platelet adhesion and stabilizes factor VIII in the circulation. When VWF is almost completely absent, as in this form, platelet plug formation is severely compromised and factor VIII activity drops markedly. The result is heavy, often mucosal, bleeding that begins in childhood and can be quite severe. This form is inherited in an autosomal recessive manner, meaning two defective copies are typically needed for the full-blown disease. Other types involve either milder quantitative deficiencies (where some VWF is present) or qualitative defects in VWF that alter its function, and most of these follow autosomal dominant patterns with milder or more variable bleeding. Therefore, the combination of autosomal recessive inheritance and near-complete absence of VWF makes this type the most severe.

Understanding how inheritance and VWF levels affect bleeding helps explain why this is the most severe form. Von Willebrand factor promotes platelet adhesion and stabilizes factor VIII in the circulation. When VWF is almost completely absent, as in this form, platelet plug formation is severely compromised and factor VIII activity drops markedly. The result is heavy, often mucosal, bleeding that begins in childhood and can be quite severe. This form is inherited in an autosomal recessive manner, meaning two defective copies are typically needed for the full-blown disease.

Other types involve either milder quantitative deficiencies (where some VWF is present) or qualitative defects in VWF that alter its function, and most of these follow autosomal dominant patterns with milder or more variable bleeding. Therefore, the combination of autosomal recessive inheritance and near-complete absence of VWF makes this type the most severe.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy